Indian literature from Ayurvedic texts and other books claim the potency of several plants in the treatment of diarrhea. As the global perspective of Ayurvedic medicines is increasing, interest regarding the scientific basis of their actions is parallelly increasing. Researchers are doing experiments to establish the relation between the claimed action and observed pharmacological activities. Economically, diarrhea is one of the major health challenges to humans as it causes loss of productive life due to premature mortality, disability and increased health-care costs. The authentic subject material has been reviewed from Ayurveda and modern medical literature. Different research and review articles were screened from different journals to establish the antidiarrheal potential of pathyadi kwatha .After reviewing the properties of the pathyadi kwatha ,it can be concluded that it possesses anti diarrheal properties and this look promising in the treatment of diarrhea.

Keywords: Polyherbal, atisara, pathya, antidiarrheal

Introduction

Diarrhea has long been recognized as an important health problem in all age groups and is a major cause of morbidity and mortality in rural communities of socio-economically backward and developing, third-world countries¹. It may be infectious or non-infectious with increase in frequency of passage of liquid faeces and alteration in stool character (amount and consistency). Infectious causative organism (virus, parasite or bacterium) spreads through contaminated food or drinking-water or from person to person as a result of poor hygiene ² while different toxins, chronic diseases or antibiotics are contributed in non infectious diarrhea ³. Economically, diarrhoea is one of the major health challenges to humans as it causes loss of productive life due to premature mortality, disability and increased health-care costs⁴.Diarrhea is described in Ayurvedic classics with the name of “Atisara”. Atisara term is made up of two terms “ati” (excessive) and “sara” (passing of liquid matter through anus). It means excessive flow of watery stool through anus ^5,6,7. Dalhana on his commentary on Sushruta samhita stated that passing of watery stools in increased quantity is a characteristic feature of atisara ⁸. Along with modern drugs it is important to identify available natural drugs as well as explore documented traditional medicinal knowledge, indigenous herbal preparation. So that it may prove an alternatives to currently used anti-diarrhoeal drugs, which are not always free from adverse effects ^9,10. So pathayadi kwatha is taken here for the review which proves that it have antidiarrheal properties¹¹ and it looks promising in the trearment of diarrhea

Method of prepration pathyadi kwatha¹²

Rt.- root, St.bk.- stem bark , Fr. P- fruit pulp, Rz.- rhizome

The coarse powder of all the ingridents are prepared separately and mixed together in the prescribed quantity. It is administered in the form of decoction as prescribed in the Ayurveda classics ¹³.

Ingredients of Pathyadi kwatha and their pharmacological and therapeutic properties

Discussion

Most ingredients have katu,tikta,kashaya rasa ,and Kashaya dominant drugs can be incorporated in the subsequent phases which facilitates for Shoshana (absorption) of liquefied or detoxified, a state produced by Tikta Rasa and Katu Rasa³⁹ Z. officinale decoction also affected host cell metabolism as seen by the reduction in colonization to HEp-2 cells of E. coli B170, E. coli E134 and that of S. flexneri in the HEp-2 pre-incubation protocol. Thus the results demonstrate that the Z. officinale decoction probably affects both bacterial and host cell metabolism to exhibit its antidiarrhoeal action⁴⁰. Musta has produced its antidiarrhoeal effect through decreasing intestinal secretions and antispasmodic effect by inhibiting the intestinal motility.⁴¹

Conclusion

This review has presented a collective knowledge on therapeutic ,Pharmacological activites of Pathyadi kwatha churna as, antibacterial, antimicrobial, antispasmodic antidiarrheal. So this review will also facilitate to gain all about the past scientific research and the necessary information about the enormous pharmacological activities of this formulation which helps the researcher to explore this formulations for the promotion of health.

* Assisitant Professor , Dept of Rasashastra & Bhaishya Kalpana Jammu Institue of Ayurveda & Research, Nardani Jammu, J&K

** Ex-Consultant Ayurveda , Sri Sri Ayurveda Jammu ,J&K

***. Prof., J.S.S Ayurveda Medical college, Mysore, Karnataka, India

References

1. De Hostos EL, Choy RKM, Nguyen T. Developing novel antisecretory drugs to treat infectious diarrhoea. Future Med Chem 2011;3(10):1317–1325.

2. World Health Organization. Integrated global action plan for the prevention and control of pneumonia and diarrhoea (GAPPD) 12 April 2013 http://www.who.int/topics/diarrhoea/en/

3. New Hampshire Department of Health and Human Services (NHDHHS). Diarrhoea (Infectious Diarrhoea). Disease handbook for childcare providers. Division of Public Health Services, Communicable Disease Control Section. Revised April, 2009. www.dhhs.nh.gov/dphs/cdcs/documents/diarrhoea.pdf

4. Guerrant RL, Oria R, Bushen OY, Patrick PD, Houpt E, Lima AAM. Global impact of diarrhoeal diseases that are sampled by Traveller: the rest of the Hippopotamus. Clinical Infectious Diseases 2005;4:5524–5530.

5. Jadavji TA. Caraka Samhita of Agnivesa, Elaborated by Caraka and Drinhbala with the Ayurveda Dipika commentry by Cakrapanidatta. Chawkhambha Vidyabhawan, Varanasi 2011.

6. Sharma PV. Susruta Samhita, with English translation of text and Dalhana commentary along with critical notes. 1st Edition. Chaukhambha Bharathi Academy, Varanasi. 2001

7. . Upadhyaya YN. Madhava Nidan of Madhava. 18th ed. Varanasi: Chaukhambha sanskrit Sansthan. 1988

8. Sharma PV. Susruta Samhita, with English translation of text and Dalhana commentary along with critical notes. 1st Edition. Chaukhambha Bharathi Academy, Varanasi. 2001

9. Jasmine TS, Jeeva S, Febreena GL, Mishra BP, Laloo RC. Wild edible plants of Meghalaya, North-east India. Nat Prod Rad 2007; 6(5): 410-426.

10. Patel JD, Patel DK, Shrivastava A, Kumar V. Screening of plant extracts used in traditional antidiarrhoeal medicines against pathogenic Escherichia coli. Sci World 2008;6 (6), 63–67

11. Shri Govind Das Bhaishjaya Ratnavali, with hindi translation by Kaviraj Ambika Datt Shastri and edited by Rajeshwar Datt Shastri reprinted 2016 varanasi Chaukhambha prakashan 7/27 page no 220.

12. i.b.i.d

13. Dr Rajendra Prasad Sharma & Dr Moharpal Meena , Bhaishajaya Kalpana vigyan first edition published by jagadeesh Sanskrit pustakalaya , jaipur page no 88

14. Sharma,P.V.Prof.;DravyagunaVijnanaVol.II, (vegetabledrugs),(2009);ChaukhambaBharti, Academy, Varanasi; PP.755-758.

15. Khanna,A.K.;Chander,R.;Kapoor,N.K.;Singh,C. andShrivastava,A.K.(1993),

               HypolipidemicactivityofTerminelischebulainrats,fitoterapia,Vol.64(4),PP.351-356.

16. Sharma,P.C.,Yelne,M.B.andDennis,T.J.(2002), DatabaseonmedicinalplantsusedinAyurveda,Vol.(5), CCRAS, PP.– 283-285.

17. Bag, A. Bhattacharyya, SK. Bharati, P. Pal, NK, and Chattopadhyay, R. Evaluation of antibacterial properties of Chebulic myrobalan (fruit of Terminalia chebula Retz.) extracts against methicillin resistant Staphylococcus aureus and trimethoprim-sulphametho-xazole resistant uropathogenic Escherichia coli, Afr. J. Plant Sci. 2009, 3(2), 025-029

18. Khan KH, Jain SK. Regular intake of Terminalia chebula can reduce the risk of getting typhoid fever. Adv Biotech 2009; 8 (9): 10-15.

19. Khan KH. The effect of regular intake of Terminalia chebula on oxidative stress in mice originated from Salmonella typhimurium. EurAsia J BioSci 2009; 3: 113-121.

20. Malckzadeh F, Ehsanifar H, Shahamat N, Levin M, Colwell RR. Antibacterial activity of black myrobalan (Terminalia chebula Retz.) against Helicobactor pyroli. Int J Antimicrob Agent 2001; 85-88.

21. Kannan P, Ramadevi SR, Hopper W. Antibacterial activity of Terminalia chebula fruit extract. African J Microbiol Res 2009; 3(4) p. 180-84.

22. Manoj kumar et al Antimicrobial activity of aqueous extract of T. chebula. Retz on gram positive andgram negative micro organisms. Int J Current Pharma Res 2009;1(1): p. 56 60.

23. Sharma PV. Susruta Samhita, with English translation of text and Dalhana commentary along with critical notes. 1st Edition. Chaukhambha Bharathi Academy, Varanasi. 2001

24. Sujoga kumar panda et al, anti- diarrheal activities of medicinal plants of Similipal Biosphere Reseve , Odisha,India.,published in Int, .J.Med.Aroma Plants ISSN 2249-4340 23 july 2012

25. Dr G.S. Pandey ,Bhavaprakash Nighantu Indian Metrica Medica of Sh. Bhava Mishra ,reprint 2004, published by Chaukhambha Bharti Academy ,Varanasi ,PP -196

26. Dr G.S. Pandey ,Bhavaprakash Nighantu Indian Metrica Medica of Sh. Bhava Mishra ,reprint 2004, published by Chaukhambha Bharti Academy ,Varanasi ,PP -197

27. Dr G.S. Pandey ,Bhavaprakash Nighantu Indian Metrica Medica of Sh. Bhava Mishra ,reprint 2004, published by Chaukhambha Bharti Academy ,Varanasi ,PP -43

28. Sujoga kumar panda et al, anti- diarrheal activities of medicinal plants of Similipal Biosphere Reseve , Odisha,India.,published in Int, .J.Med.Aroma Plants ISSN 2249-4340

29. R.Balakumbahan et al , Acorus calamus : An overview , published in journal of medicinal plants research vol 4 (25) pp 2740-2745 December special review ISSN 1996-0875 @ 2010 Academic Journals.

30. Dr G.S. Pandey ,Bhavaprakash Nighantu Indian Metrica Medica of Sh. Bhava Mishra ,reprint 2004, published by Chaukhambha Bharti Academy ,Varanasi ,PP -243.

31. Ashish Mishra et al , Therapeutic significance and pharmacological activities of antidiarrheal medicinal plants mention in Ayurveda: A review , published in journal of intercultural ethnopharmacology, 04 May, 2016.

32. Prashant B. Shamkuwar, Antispasmodic effect of Cypreus rotundus , 2012, published in Scholars research library

33. Sharma,P.V.Prof.;DravyagunaVijnanaVol.II, (vegetabledrugs),(2009);ChaukhambaBharti, Academy, Varanasi; PP.333-335

34. Bhandari,U.etal;(1995),EffectofZingiber officinaleonlipidmetabolisminalbinorabbits, Int.Sem.onRecentTrendsinPhrma.Sci., Ootacamund,18-20 Feb., Abstr.No.-A-41.

35. Poonam G.Daswani et al , Anti diarrhoeal Activity of Zingiber officnicale , published in Current science , Vol 98, no 2 , 25 january 2010

36. i.b.i.d

37. . Dr G.S. Pandey ,Bhavaprakash Nighantu Indian Metrica Medica of Sh. Bhava Mishra ,reprint 2004, published by Chaukhambha Bharti Academy ,Varanasi ,PP -127

38. 15. Ashish Mishra et al , Therapeutic significance and pharmacological activities of antidiarrheal medicinal plants mention in Ayurveda: A review , published in journal of intercultural ethnopharmacology, 04 May, 2016.

39. Harishitha kumara et al , Medohara and Lekhaniya dravyas (anti- obesity and hypolipidemic drugs) in Ayurvedic Classics: A critical review published in AYU in junw 2016 pp 14.

40. Poonam G.Daswani et al , Anti diarrhoeal Activity of Zingiber officnicale , published in Current science , Vol 98, no 2 , 25 january 2010

     

41.